Dr. Prakash Kishore Hazam

1. Ph.D from Indian Institute of Technology, Guwahati (Jan 2012 - November 2018).
2. M.Pharm (Pharmacognosy) from Sikkim Central University (August 2008 - July 2010).
3. B.Pharm from University of North Bengal (July 2004 - June 2008).

1. Postdoctoral fellow at Academia Sinica, Taiwan (January 2020 - October 2025).
2. Research Associate at NIPER Guwahati, India (June 2018 - October 2019).
3. Senior Research Fellow at Jadavpur University (November 2010 - December 2011).

I plan to explore in developing newer broad-spectrum antimicrobial peptides from natural sources such as marine and freshwater reserves in a systematic process. As we are heading towards the post antibiotic era, we must obtain novel antimicrobials for future clinical applications. Through my approach, I am confident of obtaining newer antimicrobials for clinical trials and probable applications. Along with peptides as therapeutics, I will systematically explore hybrid molecules such as peptide drug conjugate, peptide lipid conjugate, or peptide metal conjugates. The sole aim of the research is to develop novel antimicrobial formulations for clinical application. Apart from peptides, I plan to explore additional molecules of therapeutic interest from similar sources in future projects. 

List of publications:

1. SP Selvaraj, JC Chang, K Raja, JT Zhu, PK Hazam, WC Lin, JR Huang, TL Li, JY Chen. Novel self-assembled antimicrobial peptide Pardaxin hydrogel as a functional biomaterial for food packaging and preservation. Chemical Engineering Journal, 525, 170727, 2025, https://doi.org/10.1016/j.cej.2025.170727
2. A Negi, BG Yadav, CW Kuo, PK Hazam, WC Lin, OK Teh, JY Chen. A Deep-Sea probiotic platform: Dual-function biopreservation for aquaculture immunomodulation and meat shelf-life extension. Innovative Food Science & Emerging Technologies, 104, 104107, 2025, https://doi.org/10.1016/j.ifset.2025.104107
3. JC Yeh, CH Yang, PK Hazam, SP Selvaraj, YY Lin, CY Hsieh, JW Liou, JY Chen. Combination of antimicrobial peptide and clinical antibiotic shows enhanced potency toward Acinetobacter baumannii infection. European Journal of Pharmacology, 999, 177683, 2025, https://doi.org/10.1016/j.ejphar.2025.177683.
4. A Negi, CW Kuo, PK Hazam, JC Yeh, WC Lin, YC Lou, CY Yu, TL Yu, TM Lu, JY Chen. Disruption of MRSA Biofilm and Virulence by Deep-Sea Probiotics: Impacts on Energy metabolism and Host Antimicrobial Peptides. Probiotics and Antimicrobial Proteins. 1-23, 2025, https://doi.org/10.1007/s12602-025-10535-0
5. PK Hazam*, SP Selvaraj *, A Negi, WC Lin, JY Chen, Use of natural peptide TP4 as a food preservative prevents contamination by fungal pathogens. Food Chemistry. 455, 139874, 2024, https://doi.org/10.1016/j.foodchem.2024.139874 (* Joint first authors).
6. PHsien Hsu*, PK Hazam*, YH Huang, JC Yeh, YR Chen, CC Li, CF Chang, JW Liou, JY Chen, Sequential rearrangement and stereochemical reorganization to design an antimicrobial peptide with enhanced stability. Biomedicine & Pharmacotherapy, 170, 116088, 2024, https://doi.org/10.1016/j.biopha.2023.116088 (* Joint first author).
7. PHsien Hsu*, PK Hazam*, YH Huang, JC Yeh, YR Chen, CC Li, CF Chang, JW Liou, JY Chen, Optimization of sequence and chiral content enhances therapeutic potential of tilapia piscidin peptides. European Journal of Medicinal Chemistry. 265, 116083, 2024, https://doi.org/10.1016/j.ejmech.2023.116083 (* Joint first author).
8. PK Hazam*, CC Cheng*, WC Lin, CY Hsieh, PH Hsu, YR Chen, CC Li, PR Hsueh, JY Chen. Strategic modification of low-activity natural antimicrobial peptides confers antibacterial potential in vitro and in vivo. European Journal of Medicinal Chemistry. 249, 115131, 2023, https://doi.org/10.1016/j.ejmech.2023.115131 (* Joint first author).
9. JC Yeh*, PK Hazam*, CY Hsieh, PH Hsu, WC Lin, YR Chen, CC Li, JY Chen. Rational design of stapled antimicrobial peptides to enhance stability and in vivo potency against polymicrobial sepsis. Microbiology spectrum, 11 (2), 2023, https://doi.org/10.1128/spectrum.03853-22 (*Joint First Author).
10. P K Hazam*, CC Cheng*, CY Hsieh, WC Lin, PH Hsu, TL Chen, YT Lee, JY Chen. Development of Bactericidal Peptides against Multidrug-Resistant Acinetobacter baumannii with Enhanced Stability and Low Toxicity. International Journal of Molecular Sciences. 23, 2191, 2022, https://doi.org/10.3390/ijms23042191 (* Joint first author).
11. P K Hazam, C. Phukan, R. Akhil, A. Singh, V. Ramakrishnan. Antimicrobial effects of syndiotactic polypeptides. Scientific Reports. 11(1), 1-10, 2021, https://doi.org/10.1038/s41598-021-81394-2.
12. PK Hazam, JY Chen. Therapeutic utility of the antimicrobial peptide Tilapia Piscidin 4 (TP4). Aquaculture Reports. 17, 100409, 2020, https://doi.org/10.1016/j.aqrep.2020.100409.
13. PK Hazam, R Akhil, G Jerath, J Saikia, V Ramakrishnan. Topological Effects on the Designability and Bactericidal Potency of Antimicrobial peptides. Biophysical Chemistry.248, 1-8, 2019, https://doi.org/10.1016/j.bpc.2019.02.005.
14. PK Hazam, R Goyal, V Ramakrishnan. Peptide based Antimicrobials: Design Strategies and Therapeutic Potential. Progress in Biophysics and Molecular Biology. 142, 10-22, 2019, https://doi.org/10.1016/j.pbiomolbio.2018.08.006.
15. PK Hazam, A Singh, N Chaudhary, V Ramakrishnan. Bactericidal potency and extended serum life of stereo- chemically engineered peptides against Mycobacterium. International Journal of Peptide Research and Therapeutics. 25(2), 465-472, 2019, https://doi.org/10.1007/s10989-018-9690-0.
16. PK Hazam, G Jerath, A Kumar, N Chaudhary, V Ramakrishnan. Effect of tacticity-derived topological constraints in bactericidal peptides. Biochimica et Biophysica Acta - Biomembranes.1859 (8), 1388 – 1395, 2017, https://doi.org/10.1016/j.bbamem.2017.05.002.
17. PK Hazam, G Jerath, N Chaudhary, V Ramakrishnan. Peptido-mimetic Approach in the Design of Syndiotactic Antimicrobial Peptides. International Journal of Peptide Research and Therapeutics. 24, 299–307, 2018, https://doi.org/10.1007/s10989-017-9615-3.
18. S Sasidharan, PK Hazam, V Ramakrishnan. Symmetry-Directed Self-Organization in Peptide Nano-assemblies through Aromatic π– π Interactions. The Journal of Physical Chemistry B 121 (2), 404-411, 2017, https://doi.org/10.1021/acs.jpcb.6b09474.
19. G Jerath, PK Hazam, S Shekhar, V Ramakrishnan. Mapping the Geometric Evolution of Protein Folding Motor. PloS One 11 (10), e0163993, 2016, https://doi.org/10.1371/journal.pone.0163993.
20. G Jerath, PK Hazam, V Ramakrishnan. bPE toolkit: toolkit for computational protein engineering. Systems and Synthetic Biology 8 (4), 337-341, 2014, https://doi.org/10.1007/s11693-014-9156-4.
21. NR Barman, PK Kar, PK Hazam, HS Pal, A Kumar, S Bhattacharya, PK Halder. Cardioprotective effect of Urtica parviflora leaf extract against doxorubicin-induced cardiotoxicity in rats. Chinese Journal of Natural Medicines, 11 (1), 38-42, 2013, https://doi.org/10.1016/S1875-5364(13)60005-9.
22. PK Mukherjee, S Ponnusankar, S Pandit, PK Hazam, M Ahmmed, K Mukherjee. Botanicals as medicinal food and their effects on drug metabolizing enzymes. Food and chemical toxicology. 49 (12), 3142-3153, 2011, https://doi.org/10.1016/j.fct.2011.09.015.

Book Chapter

1. Vishal Chaudhari, Prakash Kishore Hazam, Subham Banerjee. Lipid Nanoarchitectonics for Natural Products Delivery in Cancer Therapy. Sustainable Agriculture Reviews 44, 2020, Publisher: Springer Nature, https://doi.org/10.1007/978-3- 030-41842-7_5.

1. Institute Post-doctoral Fellowship Academia Sinica, Taiwan, December 2020.
2. Institute fellow for pursuing Ph.D. from Indian Institute of Technology, Guwahati, January 2012
3. Selected for DST-INSPIRE fellowship from Department of Science and Technology (DST) 2011
4. University topper, Master of Pharmacognosy, Sikkim Central University, Sikkim, June 2010.