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Research

FACULTY OF SCIENCE PRESENTLY FOCUS ON RESEARCHES UNDER FOLLOWING AREAS BASED ON THE REGIONAL AND SOCIETAL HEALTH.

Value Addition to food products Genotoxicity study Phytochemistry, (Biofertilizers, Biocides, Antimicrobial compounds) Cancer genomics  Ecosystem management and restoration  Bioremediation, Phytoremediation

EXTRAMURAL AND INTRAMURAL FUNDED RESEARCH PROJECTS ONGOING

Department of Biotechnology, Government of India funded major research project entitled Characterization of high value phytochemicals of anti-diabetic and immunomodulatory properties in North Eastern banana varieties under the supervision of Dr. Ananya Kashyap and Daisy Sarma. Assam down town University, funded research project A Study of purification and characterization of protease inhibitor from edible (D. lablab) seeds and their efficacy against rice weevils under the supervision of Dr. Minakshi Bhattacharjee and Dhiman ch. Paul Assam down town University, funded research project Molecular typing of methicillin resistant strains of staphylococcus aureus on the basis of scc mec element to detect the prevalence of community acquired MARSA in hospitals.  under the supervision of Sheela Kumari Singh and Dr. Minakshi Bhattacharjee Assam down town University, funded research project Structural characterization and molecular docking of active compounds isolated from Amaranthus spinosus against Jaundice.  under the supervision of Sangita Boro and Bhriganka Bharadwaj Assam down town University, funded research project Development of Novel composite therapeutic mix having high calorie, antioxidant and antidiabetic activity. under the supervision of Daisy Sharma and Manash Pratim Sarma

EXTRAMURAL AND INTRAMURAL FUNDED RESEARCH PROJECTS COMPLETED

Department of Biotechnology, Government of India funded major research project entitled  Foldscope a Tool for Evaluation of Genotoxic Effect of Food Preservatives: A Model Experiment for Under Graduate Students of Life Science under the supervision of Dr. Jyotchna Gogoi and Dr. Papia Dutta Assam down town University, funded research project Polymorphism and expression study of heat shock protein gene in cancer cases from Assam under the supervision of Dr. Manash Pratim Sarma

PROGRESS OF THE RESEARCH ARTICLES PUBLISHED BY THE FACULTY MEMBERS

1.    Research Publications peer reviewed journals (2015) – 16

2.    Research Publications peer reviewed journals (2016) – 11

3.    Research Publications peer reviewed journals (2017) – 18

4.    Research Publications peer reviewed journals (2018) – 16

5.    Research Publications peer reviewed journals (2019) – 24

SOME OF THE RESEARCH ARTICLES PUBLISED BY THE FACULTY MEMBERS

Gohain, Anwesha, Animesh Gogoi, Rajal Debnath, Archana Yadav, Bhim P. Singh, Vijai K. Gupta, Rajeev Sharma, and Ratul Saikia. "Antimicrobial biosynthetic potential and genetic diversity of endophytic actinomycetes associated with medicinal plants." FEMS microbiology letters 362, no. 19 (2015): fnv158. Barman, Indrani, Karuna Barman, Mamta Mishra Purohit, Murchana Choudhury, Abani Kumar Choudhury, and Monjoy Kumar Choudhury. "A study of mental stress and antioxidant profile in the Assamese-speaking diabetic population of Assam, India." International Journal of Diabetes in Developing Countries 35, no. 2 (2015): 163-172. Dey, Tapan, Prachurjya Dutta, Prasenjit Manna, Jatin Kalita, Hari Prasanna Deka Boruah, Alak Kumar Buragohain, Balagopalan Unni, Dibyajyoti Ozah, Mihir Kumar Goswami, and Ratan Kumar Kotokey. "Cigarette smoke compounds induce cellular redox imbalance, activate NF-κB, and increase TNF-α/CRP secretion: a possible pathway in the pathogenesis of COPD." Toxicology research 5, no. 3 (2016): 895-904. Devi, R., B. Devi, B. G. Unni, and M. Garg. "AN IN VITRO COMPARATIVE STUDY ON ANTIOXIDANT, ANTIBACTERIAL AND NUTRACEUTICAL PROPERTIES OF THREE DIFFERENT COLOURED SCENTED RICE VARIETIES OF NORTH-EASTERN REGION." INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH 8, no. 7 (2017): 2968-2974. Chokhone, K., Nayan Talukdar, Manash Pratim Sarma, Karabi Das, and Partha Pratim Kalita. "SCREENING OF PHYTOCHEMICALS AND EVALUATION OF ANTI-MICROBIAL, ANTI-OXIDANT AND IN-VITRO ANTIDIABETIC ACTIVITY OF CRASSULA OVATA LEAVES." International Journal of Pharmaceutical Sciences and Research 8, no. 2 (2017): 859. Bordoloi, Manobjyoti, Surovi Saikia, Bhaskor Kolita, Rajeev Sarmah, Sonali Roy, and Bardwi Narzary. "Volatile Inhibitors of Phosphatidylinositol-3-Kinase (PI3K) Pathway: Anticancer Potential of Aroma Compounds of Plant Essential Oils." Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents) 18, no. 1 (2018): 87-109. Saikia, Surovi, Manobjyoti Bordoloi, Rajeev Sarmah, and Bhaskor Kolita. "Antiviral compound screening, peptide designing, and protein network construction of influenza a virus (strain a/Puerto Rico/8/1934 H1N1)." Drug development research 80, no. 1 (2019): 106-124. Saikia, Surovi, Manobjyoti Bordoloi, and Rajeev Sarmah. "Established and In-trial GPCR Families in Clinical Trials: A Review for Target Selection." Current drug targets 20, no. 5 (2019): 522-539. Sarma, Manash Pratim, Dipu Bharali, Akan Das, Minakshi Bhattacharjee, and Premashis Kar. "Single-nucleotide polymorphisms in dendritic cell (dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin) gene of hepatocellular carcinoma patients from India." (2020). Neog, Murchana, Pradip Debnath, and Stojan Radenovic. "New extension of some common fixed point theorems in complete metric spaces." Fixed Point Theory 20, no. 2 (2019): 567-580. Debnath, Pradip, Murchana Neog, and Stojan Radenović. "Set valued Reich type G-contractions in a complete metric space with graph." Rendiconti del Circolo Matematico di Palermo Series 2 (2019): 1-8. Kaushik, Gitartha, Kduplin Synnah, Kermi‐U. Tariang, Ramanujam Sunkam Narayana, and Sabitry Bordoloi. "Length–weight relationships of four indigenous fish species collected in Assam and Meghalaya, India." Lakes & Reservoirs: Research & Management 24, no. 3 (2019): 299-301. Gogoi, Kabita, Prasenjit Manna, Tapan Dey, Jatin Kalita, Bala Gopalan Unni, Dibyajyoti Ozah, and Pranab Kumar Baruah. "Circulatory heavy metals (cadmium, lead, mercury, and chromium) inversely correlate with plasma GST activity and GSH level in COPD patients and impair NOX4/Nrf2/GCLC/GST signaling pathway in cultured monocytes." Toxicology in Vitro 54 (2019): 269-279. Das, Karabi, Papia Dutta, and Jyotchna Gogoi. "‘Foldscope’-A simple and economical microscope." Journal of Biological Education (2019): 1-6. Bordoloi, Manobjyoti, Surovi Saikia, Bhaskor Kolita, Rajeev Sarmah, Sonali Roy, and Bardwi Narzary. "Volatile Inhibitors of Phosphatidylinositol-3-Kinase (PI3K) Pathway: Anticancer Potential of Aroma Compounds of Plant Essential Oils." Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents) 18, no. 1 (2018): 87-109. Some, Sudip, Onur Bulut, Kinkar Biswas, Anoop Kumar, Anupam Roy, Ipsita Kumar Sen, Amitava Mandal et al. "Effect of feed supplementation with biosynthesized silver nanoparticles using leaf extract of Morus indica L. V1 on Bombyx mori L.(Lepidoptera: Bombycidae)." Scientific reports 9, no. 1 (2019): 1-13. Sarma, Manash P., Minakshi Bhattacharjee, Premashis Kar, and Subhash Medhi. "Detection of HBV genotype C in hepatocellular carcinoma patients from North East India: a brief report." Asian Pacific journal of cancer prevention: APJCP 19, no. 7 (2018): 1741. Bharali, Dipu, Hakim B. Jebur, Debabrat Baishya, Suresh Kumar, Manash P. Sarma, Mirza Masroor, Juheb Akhter, Syed A. Husain, and Premashis Kar. "expression analysis of serum microRNA-34a and microRNA-183 in Hepatocellular Carcinoma." Asian Pacific journal of cancer prevention: APJCP 19, no. 9 (2018): 2561. Saikia, Snigdha, Prajjalendra Barooah, Mallika Bhattacharyya, Manab Deka, Bhabadev Goswami, Manash P. Sarma, and Subhash Medhi. "Polymorphisms In heat shock proteins a1b and a1l (hom) as risk factors for oesophageal carcinoma in northeast india." Asian Pacific Journal of Cancer Prevention 16, no. 18 (2015): 8227-8233. Bharali, Dipu, Manash Pratim Sarm, and Premashis Kar. "ASSOCIATION OF METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) A1298C & C667T GENE POLYMORPHISM AND HEPATOCELLULAR CARCINOMA PATIENTS FROM INDIA." Sarma, Manash Pratim, and Partha Pratim Kalita. "HEPATITIS BVirus PRECORE PROTEIN MODELING: AN EXPERIENCE FROM NEW DELHI, INDIA." Lebanese Science Journal 16, no. 2 (2015): 113. Sarma, Manash Pratim, Giasuddin Ahmed, Subhash Medhi, Dipu Bharali, Minakshi Bhattacharjee, and Premashis Kar. "Detection of Nucleoside/Nucleotide Drug Resistant Mutants in Liver Cancer Cases: An Experience from India." Exploratory Research and Hypothesis in Medicine 1, no. 3 (2016): 47-49. Devi, E. C., J. Devi, P. P. Kalita, N. Talukdar, and M. Bhattacharjee. "Phytochemical Analysis of Solanum virginianum and its Effect on Human Pathogenic Microbes with Special Emphasis on Salmonella typhi J Forensic Toxicol Pharmacol 4: 3." of 5 (2015): 2. Chokhone, K., Nayan Talukdar, Manash Pratim Sarma, Karabi Das, and Partha Pratim Kalita. "SCREENING OF PHYTOCHEMICALS AND EVALUATION OF ANTI-MICROBIAL, ANTI-OXIDANT AND IN-VITRO ANTIDIABETIC ACTIVITY OF CRASSULA OVATA LEAVES." International Journal of Pharmaceutical Sciences and Research 8, no. 2 (2017): 859. Minakshi, B., D. Jharna, E. Chanbi Devi, T. Nayan, P. K. Partha, N. Kundal, and P. S. Manash. "Phytochemical Analysis of Traditional Medicinal Plants and their Antimicrobial Activity: An Experience from North East India." Journal of Pharmaceutical Research 1, no. 1 (2014): 1-6. Bhattacharjee, M., K. Mahanta, and M. P. Sarma. "Synergistic Effect of Cyperus odoratus & PGPR Strain in Hydrocarbon Uptake From Oil Contaminated Soil." Biotechnol Ind J 14, no. 3 (2018): 165. Minakshi, Bhattacharjee, Boro Jutika, Singha Swati, Boro Hitesh, Gengla Narbu, and Manash Pratim Sarma. "Common ancestry & genetic diversity of few indigenous chilli land races of North East India." South Asian Journal of Experimental Biology 7, no. 6 (2017): 240-247. Paul, Dhiman Chandra, Minakshi Bhattacharjee, and Manash Pratim Sarma. "In Silico Study on Tea Flavanoids as Anticlastogens." BHATTACHARJEE, MINAKSHI, SEMA Y. VITOLU, and MANASH PRATIMSARMA. "STUDY ON MULTIPOTENT MEDICINAL ASPECTS OF SCHIMA WALLICHII (BARK) FROM NAGALAND, NE INDIA." Asian J Pharm Clin Res 12, no. 3 (2019): 155-158. Sapam, Redina, Partha Pratim Kalita, Manash Pratim Sarma, Nayan Talukdar, and Harajyoti Das. "SCREENING OF PHYTOCHEMICALS AND DETERMINATION OF TOTAL PHENOLIC CONTENT, ANTI-OXIDANT AND ANTIMICROBIAL ACTIVITY OF METHANOLIC EXTRACT OF PIPER NIGRUM LEAVES." Pharmaceutical Research 8, no. 02 (2018). Sarma, M. P. "Analysis of Cyanide Concentration in Five Selected Bamboo Shoots Consumed in North East India." Lepcha, Lhakit, Manash Pratim Kashyap, B. G. Unni, and Miss Lhakit Lepcha. "Assessment of Oral Cellular proliferative activity among Tamol chewers population in Assam, India." Sarma, Manash Pratim, Dipu Bharali, Akan Das, Minakshi Bhattacharjee, and Premashis Kar. "Single-nucleotide polymorphisms in dendritic cell (dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin) gene of hepatocellular carcinoma patients from India." (2020). Garg, Manashi, and Manash Pratim Sarma. "Nanobiotechnology in Understanding Cancer Biology."

 

SOME OF THE CONFERENCE PUBLICATIONS MADE BY THE FACULTY MEMBERS

B.G. Unni (2015), Chronic Obstructive Pulmonary disease; Gene – Environment interaction? A sensitive issue in Coal miners, Society of Neuro Chemistry of India, NEHU.pp-9 Luna Dutta Baruah ,Rojita K Devi& BG Unni (2015) AN ETHNOBOTANICAL SURVEY OF THE MEDICINAL PLANTS OF MANIPUR USED IN TREATING SOME COMMON AILMENTS, Annam Festival  December 7-9 , Trivandrum Kerala.pp34 BG Unni (2015) Simple, Viable and Eco-friendly technology for muga sericulture –future scope for entrepreneurs. Conference on Promotion of Rural Micro-enterprises: Prospects & Challenges. At National Institute of Rural development and Panchayati Raj, NE Region Khanaparta Assam December 7-8  BG Unni (2015) Impact of Environmental Pollutants on Human health: Epidemiological Molecular and Biochemical Studies. Annual conference of Society of Neurochemistry of India , 19-21st December NEHU Shillong-pp23 BG Unni (2016) Impact Of Environmental Pollutants on Human health: Epidemiological Molecular and Biochemical Studies .International congress Scenario Biotechnology 20126- Indore  March 10-16 pp89 TapanDey, KabitaGogoi, JatinKalita, MinakshiBhattacharjeeBalagopalanUnni, (2016)COPD and its Association with Gene Polymorphism and Cigarette Smoke, Conference COPD, Brisbane Australia June pp67 LhakitLepcha, M. Kashyap, A.C. Deka and B G Unni (2016), Assessment of Oral Cellular proliferity activity among Tamul Chewers population in Assam, All India Medical Laboratory Technology Annual Meeting, Patna in April ,pp81. J. Majumdar, S. Boro, B. Bharadwaj, R.Das, G. Hussain, P. Borah, H. Das, B.G. Unni  (2016) Screening of Phytochemicals from the leaves of Amaranthusspinosus and its anti-microbial properties against Staphylococcus aureus , 57th International annual Conference of the Association of Microbiologists of India (AMI-2016), (24 – 27 November),.pp45 Rubi Das, SangitaBoro, BhrigankaBharadwaj, JayashreeMajumdar, Gultaj Hussain, B.G. Unni (2016),  Phytochemical Characterization and Antimicrobial properties of Amaranthusspinosuslinn against enteric bacteria, 57th International annual Conference of the Association of Microbiologists of India (AMI-2016), (24 – 27 November).pp34 Mansi Garg (2016) Drug incorporated polyelectrolyte complex biomaterial against bacteria causing chronicity’ and ‘Physicochemical characterization of Chloramphenicol encapsulated polyelectrolyte composite nanocapsule against chronicity’ International conference on Technologically Advanced Materials and Asian Meeting on Ferroelectricity (ICTAM-AMF10)  University of Delhi, Delhi October pp-021 S. SINGH1, M. SENGUPTA, B.G. UNNI2 (2016) Study Of The Prevalence Of Methicillin Resistant Staphylococcus Aureus In The Nursing Community. 57th International annual Conference of the Association of Microbiologists of India (AMI-2016), (24 – 27 November).pp28 EeshitaDhar, Sakshita Agnihotri3, B. G. Unni2 (2016) Comparison of vancomycin against methicilin resistant Staphylococcus aureus and methicilin sensitive S. aureus isolated at a tertiary care centre in Jaipur, India57th International annual Conference of the Association of Microbiologists of India (AMI-2016), (24 – 27 November).pp56 Sebrin Jahan Islam, Prasenjit Manna, BalagopalanUnni, JatinKalita, (2017) Effect of air borne heavy metal pollution in antioxidative defense mechanisms of Muga Silkworm, Antheraeaassamensis, in the abstract Molecular Insect Science (February 6 - 8, 2017), Assam Agricultural University, Jorhat, Assam Pp45. TapanDey, Prachurjya Dutta, Prasenjit Manna, JatinKalita, Hari PrasannaDeka Boruah, Alak Kumar Buragohain, BalagopalanUnni, (2017)Effect of Cigarette Smoke Compounds in the Pathogenesis of Copdand its prevention by Curcumin, in the abstract International Conference on Advances in Cellular, Genomic and Epigenomic Insights on Environmental Mutagenesis and Health & 41st Annual Meeting of Environmental Mutagen Society of India (EMSI) School of Life Sciences, Manipal University, Manipal, Karnataka, (27th – 29th) pp45 B G Unni (2017). “Unique Biodiversity and Bioresources of North ast Region: Proper consideration and utilization abstract in proceedings national seminar on Promotion and Protection of Traditional Health Care remedy, Gauhati University on 24 – 26 March, 2017.p-4-6 Manashi Garg, Banasmita Devi, B.G Unni (2017). An in vitro comparative study on antioxidant, antibacterial and nutraceutical properties of three different colored scented rice varieties of north eastern region. Abstract in Natural Products Chemistry as a Curative Medicine” at the 3rd World Congress on Natural Product Chemistry and Research American Journal of Ethanomedicine,4:2 DOI 1021767/2348-9502-CI-002: Banasmita Devi, ManashiGarg, Rashna Devi and B.G Unni (2017). Extraction, isolation and Charactrtization of Tocotrienol from glutinous black rice variety of North East India and its active nanoformulation against chronicity.  Abstract in Natural Products Chemistry as a Curative Medicine” at the 3rd World Congress on Natural Product Chemistry and Research , American Journal of Ethanomedicine,4:2 DOI 1021767/2348-9502-CI-002 Sebrin Jahan Islam, Prasenjit Manna, Balagopalan Unni, Jatin Kalita, (2017) Effect of air borne heavy metal pollution in antioxidative defense mechanisms of Muga Silkworm, Antheraea assamensis, in the abstract Molecular Insect Science (February 6 - 8, 2017), Assam Agricultural University, Jorhat, Assam Pp45. Tapan Dey, Prachurjya Dutta, Prasenjit Manna, Jatin Kalita, Hari Prasanna Deka Boruah, Alak Kumar Buragohain, Balagopalan Unni, (2017). Effect of Cigarette Smoke Compounds in the Pathogenesis of Copdand its prevention by Curcumin, in the abstract International Conference on Advances in Cellular, Genomic and Epigenomic Insights on Environmental Mutagenesis and Health & 41st Annual Meeting of Environmental Mutagen Society of India (EMSI) School of Life Sciences, Manipal University, Manipal, Karnataka, (27th – 29th)  pp45 B G Unni (2017). “Unique Biodiversity and Bioresources of North ast Region: Proper consideration and utilization abstract in proceedings national seminar on Promotion and Protection of Traditional Health Care remedy, Gauhati University on 24 – 26 March, 2017.p-4-6 Manashi Garg, Banasmita Devi, B.G Unni (2017). An in vitro comparative study on antioxidant, antibacterial and nutraceutical properties of three different colored scented rice varieties of north eastern region. Abstract in Natural Products Chemistry as a Curative Medicine” at the 3rd World Congress on Natural Product Chemistry and Research American Journal of Ethanomedicine,4:2 DOI 1021767/2348-9502-CI-002: Banasmita Devi, ManashiGarg, Rashna Devi and B.G Unni (2017). Extraction, isolation and Charactrtization of Tocotrienol from glutinous black rice variety of North East India and its active nanoformulation against chronicity. Abstract in Natural Products Chemistry as a Curative Medicine” at the 3rd World Congress on Natural Product Chemistry and Research , American Journal of Ethanomedicine,4:2 DOI 1021767/2348-9502-CI-002 Sangita Boro, Jayashree Majumdar, Surabhi Doley, Balagopalan Unni (2018). Antimicrobial activity of the methanolic leaf extract of Amaranthus spinosus and a comparative analysis of its antioxidant activity against a standard drug silymarin. Abstract Drug Discovery from Natural Products and their traditional uses. 23. B G Unni (2018) “Biomolecules of plant, insect and microbe based and its functional properties to enhance the silk production” abstract in souvenir/ abstract in National Conference in Sericulture at Raiganj University, West Bengal (30th – 31st January, 2018). Sabrin Jahan Islam and BG Unni (2018). Impact of Cadmian and lead on the antioxidant defence mechanism of Eri Silk Worm.  Abstract – Conference Banya Sericulture and Seri Biodiversity for economic upliftment. 12th & 13th March, 2018. CMER&TI, Central Silk Board, Lahdoigarh, Jorhat.

 

MAJOR SCIENTIFIC EVENTS ORGANIZED

2018: Organized national level seminar on “Translational Drug Discovery: Current Tends and Future Interventions” in association with Society of Biological Chemistry (India), North East Chapter and Tea Consortium, Tocklai Jorhat.

2019: Organized national level seminar on “Bio exploration for human welfare-An integrative approach”. On behalf of the organizing committee in collaboration with IASST (Institute of Advance Studies in Science and Technology) Assam and Society of Biological Chemistry (India), North East Chapter.

 

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