Dr. Suman Kumar Samanta

PROFESSIONAL & RESEARCH EXPERIENCE

Associate Professor | Assam down town University, Guwahati

March 2023 – Present

CSIR-Pool Scientist | IASST, Guwahati

February 2020 – February 2023

Scientist-C | IASST, Guwahati

May 2017 – February 2020

Research Associate | IASST, Guwahati

March 2017 – May 2017

Postdoctoral Fellow | University of Pittsburgh, USA

August 2014 – November 2016

Research Associate | CSIR-Indian Institute of Chemical Biology, Kolkata

April 2014 – July 2014

PATENTS:

Granted

1. Process for the isolation of organic compounds useful for the treatment of cancer. US patent. Pub No. US2013/0065932A1; 2013.
2. Two main component molecules: Mahanine and Mahanimbine (Dehydroxy-Mahanine) from Murrayakoenigii for the treat in glioblastoma and cervical carcinoma and Mahanimbine exhibits broad spectrum of anti-cancer. Indian Patent, Application No.690/DEL/2011. Patent no. 352973.
3. Rice bran oil from the scented rice (Joha) variety rich in ω−6 and ω−3 fatty acid, efficacious to diabetes. Indian Patent, Application No.201831035549. Patent no. 405790.

Filed

1. Diseases Subtype Irrespective Breast Cancer Regulation Through Dietary Phytochemical Mahanine. Indian Patent, Application No. 201831030091.
2. A Herbal Composition from PremnaHerbacea, useful for prevention of Obesity and Type 2 Diabetes and a method for its Extraction. Application No. 201831046382.
3. A herbal extract from Lysimachia candida for treatment of obesity and related hyperglycemia and a method for its extraction. Application No.201931019887.

ORIGINAL RESEARCH ARTICLES PUBLISHED AS FIRST AUTHOR AND/OR CORRESPONDING AUTHOR

1. Samanta SK, Sehrawat A, Kim SH, Hahm ER, Shuai Y, Roy R, Pore SK, Singh KB, Christner SM, Beumer JH, Davidson NE, Singh SV. Disease Subtype- Independent Biomarkers of Breast Cancer Chemoprevention by Ayurvedic Medicine Component Withaferin A. JNCI-Journal of the National Cancer Institute; 2016, 109(6), djw293; ISSN: 0027-8874. https://doi.org/10.1093/jnci/djw293.[Impact Factor: 11.82, No. of citation: 36].
2. Samanta SK, Dutta D, Roy S, Bhattacharya K, Sarkar S, Dasgupta AK, Pal BC, Mandal C, Mandal C.Mahanine,a DNA minorgroove binding agent exerts cellular cytotoxicity with involvement of C-7-OH and -NH functional groups. J Med Chem; 2013, 56, 5709-5721. ISSN: 0022-2623. https://doi.org/10.1021/jm400290q. [Impact Factor: 8.04; No. of citation: 47].
3. Samanta SK, Bhattacharya K, Mandal C, Pal BC. Identification and quantification of the active component quercetin 3-O-rutinoside from Barringtonia racemosa, targets mitochondrial apoptotic pathway in acute lymphoblastic leukemia. J Asian Nat Prod Res; 2010; 12: 639-48. ISSN: 1028-6020. https://doi.org/10.1080/10286020.2010.489040. [Impact Factor: 1.61; No. of citation: 33].
4. Samanta SK*, Kandimalla R, Gogoi B, Dutta KN, Choudhury P, Deb PK, Devi R, Pal BC, Talukdar NC. Phytochemical Portfolio and Anticancer Activity of Murraya koenigii and its Primary Active Component, Mahanine. Pharmacological Research; 2018; 129:227-236. ISSN: 1043-6618. https://doi.org/10.1016/j.phrs.2017.11.024. [Impact Factor: 10.33; No. of citation: 46].
5. Samanta SK, Lee J, Hahm ER, and Singh SV. PeptidylProlylCis/Trans Isomerase Pin1 Regulates Withaferin A-Mediated Cell Cycle Arrest in Human Breast Cancer Cells. Molecular Carcinogenesis; 2018; 57(7):936-946. ISSN: 0899-1987. https://doi.org/10.1002/mc.22814. [Impact Factor: 5.14; No. of citation:12].
6. Das M, Kandimalla R, Gogoi B, Dutta KN, Choudhury P, Devi R, Dutta PP, Talukdar NC, Samanta SK*. Mahanine, A dietary phytochemical, represses mammary tumor burden in rat and inhibits subtype regardless breast cancer progression through suppressing self-renewal of breast cancer stem cells. Pharmacological Research; 2019; 146; 104330. ISSN: 1043-6618. https://doi.org/10.1016/j.phrs.2019.104330. [Impact Factor: 10.33; No. of citation:21].
7. Choudhury P, Dutta KN, Singh A, Malakar D, Pillai M, Talukdar NC, Samanta SK*, Devi R*. Assessment of nutritional value and quantitative analysis of bioactive phytochemicals through targeted LC‐MS/MS method in selected scented and pigmented rice varietals. Journal of Food Science; 2020; 85(6), 1781-1792. ISSN: 0022-1147. https://doi.org/10.1111/1750-3841.15164.[Impact Factor: 3.69; No. of citation:11]
8. Kandimalla R, Das M, Barge SR, Sarma PP, Koiri DJ, Devi A, Karki AK, Kumar A, Devi R, Pal BC, Talukdar NC, Samanta SK*. Variation in biosynthesis of an effective anticancer secondary metabolite, mahanine in Murraya koenigii, conditional on soil physicochemistry and weather suitability. Sci Rep; 2020; 10(1):20096. ISSN: 2045-2322. https://doi.org/10.1038/s41598-020-77113-y. [Impact Factor: 5.0, No. of citation:12].
9. Choudhury P, Dutta KN, Talukdar NC, Samanta SK*, Devi R*. Quantitative analysis of bio-active phytochemical(s) in selected scented rice varieties (Oryza sativa) reveals its intake towards advantage against metabolic disorders. IJTK; 2020. 20 (1), 210-220. ISSN: 0972-5938. http://nopr.niscpr.res.in/handle/123456789/56286. [Impact Factor: 1.09, No. of citation:4].
10. Kandimalla R, Das M, Bhattacharjee S, Choudhury P, Devi R, Talukdar NC, Samanta SK*. Effect of multiple doses of N-methyl-N-nitrosourea, an end product of methylguanidine (found in processed food), on the fertility of female Swiss albino mice. Heliyon; 2021. 7(4), e06738. ISSN: 2405-8440. https://doi.org/10.1016/j.heliyon.2021.e06738. [Impact Factor:3.78, No. of citation:3].
11. Samanta SK*,Choudhury P, Sarma PP, Gogoi B, GogoiN, Devi R. Dietaryphytochemicals/nutrients as promising protector of breast cancer development: A comprehensive analysis. Pharmacological Rep; 2022, 1-19.ISSN: 1734-1140.https://doi.org/10.1007/s43440-022-00373-0. [Impact Factor:3.92, No. of citation:5].
12. Choudhury P, Samanta SK*, Bhattacharjee S, Sarma H, Devi R. Chemical composite of indigenous whole grain scented joha rice varietal prevents the type 2 diabetes in rats through ameliorating the insulin sensitization by IRS-1/AKT/PI3K/IRS-1/AKT/PI3K signalling cascade, Food Funct., 2022,13, 11879-11895; ISSN: 2042-650X. https://doi.org/10.1039/D2FO02373C.[Impact Factor: 6.32].
13. Samanta SK*, Choudhury P, Kandimalla R, Aqil F, Moholkar DN, Gupta RC, Das M, Gogoi B, Gogoi N, Sarma PP, Devi R, Talukdar NC. Mahanine mediated therapeutic inhibition of estrogen receptor-α and CDK4/6 expression, decipher the chemoprevention-signaling cascade in preclinical model of breast cancer. Journal of Ethnopharmacology 2023: 117235. [Impact Factor: 5.4].
14. Samanta SK, Talukdar NC. Pharmacological efficacy of Allium hookeri, Premna herbacea and Lysimachia candida in regulating metabolic dysfunctions. Annals of Multidisciplinary Research, Innovation and Technology (AMRIT). 2023. 2(1), 21-44.
15. Choudhury P, Gogoi B, Gogoi N, Talukdar NC, Devi R, Samanta SK*. Exploring the Role of Omega-6/Omega-3 Ratio in Disease Management: Insights from Dietary Impact and Molecular Docking Analyses. Annals of Multidisciplinary Research, Innovation and Technology (AMRIT). 2023. 2(2), 1-15. 
16. Suman Kumar, S., Deka, D., Kandimalla, R., Ghosh, A., Barge, S.R., Kashyap, B., Bharadwaj, S. and Talukdar, N.C.,  Emerging Natural and Synthetic Compounds in the Management of Diabetic Neuropathy: Targeting Oxidative Stress and Inflammation. Annals of Multidisciplinary Research, Innovation and Technology (AMRIT). 2024. 3(1), 15-22.
17. Deka, D., Sarma, M.P., Das, S., Baruah, M., Longkumer, I., Acharjee, G., Chakraborty, D., Dey, D., Chakraborty, S., Talukdar, N.C. and Samanta, S.K., 2025. Correlation of specific addictions with cancer sites identified among patients in Northeast India. Scientific Reports, 15(1), p.27598. [Impact Factor: 3.9].
18. Dweh, T. J., Taye, M., Deka, D., Samanta, S. K., & Talukdar, N. C. (2025). Phytochemicals as Radioprotective and Radiosensitizing Agents in Cancer Radiotherapy: Advances, Challenges, and Future Perspectives. Planta Medica. https://doi.org/10.1055/a-2654-6072. [Impact Factor: 2.1]
19. Baskar, S., Paul, D. C., Taye, M., Baig, K., Kubendiran, B., Samanta, S. K., & Kole, G. K. (2026). Structural, photophysical, and electrochemical characterization with cytotoxic evaluation of N-methylated pyridinium─ vinyl─ arene dyes in breast cancer cells. Journal of Molecular Structure, 1368, 146214. [Impact Factor: 4.9]
20. Dweh, T. J., Taye, M., Deka, D., Samanta, S. K., & Talukdar, N. C. (2026). Fusobacterium nucleatum in oral squamous cell carcinoma: molecular mechanisms, tumor microenvironment and translational implications. Archives of microbiology, 208(8), 423. [Impact Factor: 3.4].

ORIGINAL RESEARCH ARTICLES PUBLISHED AS CO-AUTHOR

1. Sehrawat A, Roy R, Pore SK, Hahm ER, Samanta SK, Singh KB, Kim SH, Singh K, Singh SV. Mitochondrial Dysfunction in cancer chemoprevention by phytochemicals from dietary and medicinal plants. Seminars in Cancer Biology;2017;47:147-153. ISSN: 1044-579X. [Impact Factor: 17.01; No. of citation: 37].
2. Sarkar S, Dutta D, Samanta SK, Bhattacharya K, Pal BC, Li J, Datta K, Mandal C, Mandal C. Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo. Int J Cancer; 2013; 132:695-706. ISSN: 0020-7136. https://doi.org/10.1002/ijc.27687. [Impact Factor: 7.32; No. of citation: 69]
3. Bhattacharya K, Samanta SK, Tripathi R, Mallick A, Chandra S, Pal BC, Shaha C, Mandal C. Apoptotic effects of mahanine on human leukemic cells are mediated throughcrosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways. BiochemPharmacol; 2010; 79: 361-72. ISSN: 0006-2952. https://doi.org/10.1016/j.bcp.2009.09.007. [Impact Factor: 6.1; No. of citation:99]
4. Mallick S, Ghosh P, Samanta SK, Kinra S, Pal BC, Gomes A, Vedasiromoni JR. Corchorusin-D, A saikosaponin-like compound isolated from Corchorusacutangulus Lam., targets mitochondrial apoptotic pathways in leukemic cell lines (HL-60 and U937). Cancer ChemotherPharmacol; 2010; 66(4):709-19. ISSN: 0344-5704. https://doi.org/10.1007/s00280-009-1214-3. [Impact Factor: 3.29; No. of citation:24]
5. Das R, Bhattacharya K, Sarkar S, Samanta SK, Pal BC, Mandal C. Mahanine synergistically enhances cytotoxicity of 5- fluorouracil through ROS-mediated activation of PTEN and p53/p73 incolon carcinoma. Apoptosis; 2014; 19(1):149-64. ISSN: 1360-8185. https://doi.org/10.1007/s10495-013-0907-6. [Impact Factor: 5.56; No. of citation: 45]
6. Das R, Bhattacharya K, Samanta SK, Pal BC, Mandal C. Improved chemosensitivity in cervical cancer to cisplatin: Synergistic activity of mahanine through STAT3 inhibition. Cancer letters; 2014; 351 (1), 81- 90. ISSN: 0304-3835.https://doi.org/10.1016/j.canlet.2014.05.005. [Impact Factor: 9.76; No. of citation: 59]
7. Bhattacharya K, Bag AK, Tripathi R, Samanta SK, Pal BC, Shaha C, Mandal C. Mahanine, a novel mitochondrial complex-III inhibitor induces G0/G1 arrest through redox alteration-mediated DNA damage response and regresses glioblastoma multiforme. Am J Cancer Res; 2014; 4(6):629-4. ISSN: 2156-6976.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266700/. [Impact Factor: 5.94; No. of citation: 57]
8. Kim SH, Hahm ER, Arlotti JA, Samanta SK, Moura MB, Thorne SH, Shuai Y, Anderson CJ, White AG, Lokshin A, Lee J, Singh SV. Withaferin A inhibits in vivo growth of breast cancer cells accelerated by Notch2 knockdown. Breast Cans Res & Treat; 2016; 157 (1), 41-54. ISSN: 0167-6806. https://doi.org/10.1007/s10549-016-3795-y. [Impact Factor: 4.62, No. of citation: 26].
9. Sarkar Bhattacharya S, Mandal C, Albiez RS, Samanta SK, Mandal C. Mahanine drives pancreatic adenocarcinoma cells into endoplasmic reticular stress-mediated apoptosis through modulating sialylation process and Ca2+-signaling. Sci Rep; 2018; 2; 8(1):3911. ISSN: 2045-2322.https://doi.org/10.1038/s41598-018-22143-w. [Impact Factor: 5.00; No. of citation:12].
10. Sehrawat A, Samanta SK, Hahm ER, Croix CS, Watkins S, Singh SV. Withaferin A-mediated apoptosis in breast cancer cells is associated with alterations in mitochondrial dynamics. Mitochondrion; 2019; 47, 282-293. ISSN: 1567-7249.https://doi.org/10.1016/j.semcancer.2016.11.009.[Impact Factor: 4.53; No. of citation:31].
11. Majumder M, Debnath S, Gajbhiye R, Saikia R, Gogoi B, Samanta SK, Das D, Biswas K, Jaisankar P,Mukhopadhyay R. Ricinuscommunis L. fruit extract inhibits migration/invasion, induces apoptosis in breast cancer cells and arrests tumor progression in vivo. Sci Rep; 2019; 9(1):14493. doi: 10.1038/s41598-019-50769-x. ISSN: 2045-2322. https://doi.org/10.1038/s41598-019-50769-x.[Impact Factor: 5.00, No. of citation:47].
12. Kashyap B, Barge SR, Bharadwaj S, Deka B, Rahman S, Ghosh A, Manna P, Dutta PP, Sheikh Y, Kandimalla R, Samanta SK, et al. Evaluation of therapeutic effect of Premna herbacea in diabetic rat and isoverbascoside against insulin resistance in L6 muscle cells through bioenergetics and stimulation of JNK and AKT/mTOR signaling cascade. Phytomedicine; 2021; 93, 153761. ISSN: 0944-7113.https://doi.org/10.1016/j.phymed.2021.153761. [Impact Factor: 6.66, No. of citation:8].
13. Barge SR, Deka B, Kashyap B, Bharadwaj S, Kandimalla R, Ghosh A, Samanta SK, et al. Astragalin mediates the pharmacological effects of Lysimachia candida Lindl on adipogenesis via downregulating PPARG and FKBP51 signaling cascade. Phytotherapy Research; 2021. 35:6990–7003.ISSN: 0951-418X. https://doi.org/10.1002/ptr.7320 [Impact Factor: 6.39, No. of citation:3].
14. Sarma PP, Gurumayum N, Samanta SK, Khound P, Kumari S, Devi D, Barman J, Banerjee SK, Devi R. Pharmacologically active chemical composite of Musa balbisiana ameliorates oxidative stress, mitochondrial cellular respiration, and thereby metabolic dysfunction. Journal of Food Biochem; 2022, 314347, ISSN: 1745-4514. https://doi.org/10.1111/jfbc.14347 [Impact Factor: 3.65, No. of citation: 2].
15. Kashyap B,  Saikia K, Samanta SK, Thakur D, Banerjee SK,  Borah JC, Talukdar NC. Kaempferol 3-O-rutinoside from Antidesmaacidum Retz. Stimulates glucose uptake through SIRT1 induction followed by GLUT4 translocation in skeletal muscle L6 cells, Journal of Ethnopharmacology; 2023, 115788. ISSN: 0378-8741. https://doi.org/10.1016/j.jep.2022.115788. [Impact Factor: 5.2, No. of citation: 4].
16. SK Pore, SK Samanta, B Gogoi, ER Hahm. Editorial: Phytochemicals in cancer prevention and therapeutics: Current advancement and future perspective. Frontiers in Pharmacol, 2023, 14, 495. [Impact Factor: 6.0]
17. Kusza DA, Venter GA, Mabunda M, Biwi J, Samanta SK, Klinck JD, Singh SV, Hunter R,  Kaschula CH. Finding the ajoene sweet-spot: structure-activity relations that govern its blood stability and cancer cytotoxicity. ChemMedChem, 2024; https://doi.org/10.1002/cmdc.202400087 [Impact Factor: 3.4].
18. Kandimalla, R.; Moholkar, D.N.; Samanta, S.K.; Tyagi, N.; Aqil, F.; Gupta, R. Oncogene Downregulation by Mahanine Suppresses Drug-Sensitive and Drug-Resistant Lung Cancer and Inhibits Orthotopic Tumor Progression. Cancers, 2024, 16, 3572. https://doi.org/10.3390/cancers16213572. [Impact Factor: 4.4].
19. Raj G, Samanta SK, Talukdar NC. Influence of Animal Gut Microbiota on Rice Seedling Growth and Endophytic Bacterial Populations. Annals of Multidisciplinary Research, Innovation and Technology (AMRIT). 2024. 3(2), 8-17.
20. Shadad M, Samanta SK, Baruah J, Deka S, Raj G, Talukdar NC. Comparative Analysis of Endophytic Bacterial Localization and Microbiome Diversity in Plant Varieties under Varied Growth Conditions through Microscopic Imaging and Sequencing Techniques. Frontiers in Microbiology, 2025. https://doi.org/10.3389/fmicb.2025.1568209 [Impact Factor: 4.5].
21. Chutia B, Gogoi RR, Shivam P, Samanta SK, et al. Exopolysaccharides of Potential Probiotic Bacteria Bacillus subtilis BB2: Characterization, Antioxidant and Antibiofilm Activities. Food Biotechnology. https://doi.org/10.1080/08905436.2025.2539363 [Impact Factor: 1.8].

Book Chapter:

1. Sehrawat A, Samanta SK, Kim SH, Hahm ER, and Singh SV. Scientific Evidence for Anticancer Effects of Withania somnifera and Its Primary Bioactive Component Withaferin A. Science of Ashwagandha: Preventive and Therapeutic Potentials. Springer, 2017. 175-196.10.1007/978-3-319-59192-6_8.
2. Samanta SK, Deka D, Pal BC, Talukdar NC. Exploring the Anticancer Potential and Method of Identification, Isolation, Purification, and Characterization of Bioactive Compounds from Selected Indian Medicinal Plants. Innovations in Bioactive Compound Discovery. Cambridge Scholars Publishing, ISBN: 1-0364-5515-7; 2025. 154-168.

Book:

1. Samanta SK, Talukdar NC. Innovations in Bioactive Compound Discovery. ISBN: 1-0364-5515-7, https://www.cambridgescholars.com/product/978-1-0364-5515-6. 1-184.

Conference Publication:

1. Samanta SK, Singh SV. Pin1 is a novel target of withaferin A, a mammary cancer chemopreventative steroidal lactone from Withania somnifera. Cancer Research 76 (14 Supplement), 2015, 830-830.
2. Hahm ER, Samanta SK, Sehrawat A, Kim SH, Pore SK, Singh KB, Christner SM, Shuai Y, BeumerJH, RoyR, Davidson NE, Singh SV. Disease subtype independent biomarkers of breast cancer prevention by withaferin a. Cancer Research 77 (13 Supplement), 2016, 5270-5270.
3. Kandimalla R, Aqil F, Moholkar DN, Samanta SK, Gupta RC. Mahanine, a carbazole alkaloid attenuates lung cancer progression. Cancer Research 82 (12_Supplement), 2022, 707-707.

Google Scholar link:

https://scholar.google.co.in/citations?user=pu_NZ7cAAAAJ&hl=en&oi=sra

REVIEWER/EDITORIAL ROLE

As acted as reviewer for the following journals: Phytomedicine; Frontiers in Pharmacol; All Life; American Journal of Reproductive Immunology; Drug and Chemical Toxicology; Journal of Herbal Medicine; Tissue and Cells; Saudi Pharmaceutical Journal; Journal of Food and Drug Analysis; etc.

FUNDED PROJECT EXECUTED OR ONGOING

INVITED LECTURES & SCIENTIFIC PRESENTATIONS

 Invited lecture: “Natural Product Based Drug Discovery: A Bench to Bedside Approach”, Gauhati University.

 Invited lecture: “Confocal Microscopy, its Principle and Application”, DST-STUTI Programme, IASST.

 Invited lecture: “High Performance Liquid Chromatography (HPLC): An Advanced Technique for Separation Chemistry”, DST- STUTI Programme, Gauhati University.

 Invited lecture: “Writing Journal Papers”, FDP, Assam down town University.

 Invited lecture: “Chemotaxonomy and the Role of Plant Secondary Metabolites in Modern Drug Discovery”, FDP, Assam down town University.

 Scientific presentations at Bose Institute, Society of Biological Chemists (India), Indian Association for Cancer Research, Indian Science Congress, AACR Annual Meeting, NSARA-2023, IACR Annual Meeting 2026 and International Conference on Biodiversity 2026.

FELLOWSHIPS & AWARDS

 Erasmus+ Fellowship for participation in a faculty development programme at University of Life Sciences “King Mihai I”,

Timișoara, Romania.

 Senior Research Associate under CSIR Scientist Pool Scheme, December 2019.

 CSIR Senior Research Fellowship (SRF), April 2011.

 Merit Scholarship under the National Scholarship Scheme for higher position in Higher Secondary examination.

ACADEMIC ADMINISTRATION & LEADERSHIP

•  Associate Dean (FRIC), Faculty of Science, Assam down town University.

   Member Secretary, Purchase Committee, Faculty of Science — coordination and oversight of faculty procurement activities.

   In-Charge, Central Instrumentation Facility (CIF), Faculty of Science.

   Member, Seed Money Management Grant Committee, Faculty of Science.

   Member, Faculty Research Committee (FRC), Faculty of Science.

   Team Leader, NAAC Criterion 3, Faculty of Science — coordination of research, innovation and extension-related activities.

   Scientific Coordinator for execution of ISO 9001:2015 certification activities at IASST, Guwahati.

   Member of scientific instrument purchase and policy-making committees.

   Developed/executed an online CIF portal for IASST.

EDITORIAL & PEER-REVIEW ACTIVITIES

• Reviewer for journals including Phytomedicine, Frontiers in Pharmacology, All Life, American Journal of Reproductive

  Immunology, Drug and Chemical Toxicology, Journal of Herbal Medicine, Tissue and Cells, Saudi Pharmaceutical Journal and

  Journal of Food and Drug Analysis.

  Editorial Board Member: Frontiers in Pharmacology.