Title: Antiamnesic potential of Crataeva nurvala buch-ham extract: a mechanism based study
Atanu Bhattacharjee*, Saikat Sen, Biplab kumar Dey
Faculty of Pharmaceutical Science, Assam down town University, Panikhaii, Guwahati, Assam - 781026
*E-mail : atanu1983@gmail.com; Mob: +91-8073612051
MODE OF PAPER PRESENTATION: ORAL/ POSTER/ E-PRESENTATION
TYPE OF PAPER: RESEARCH/ REVIEW
Crataeva nurvala Buch-Ham, a well explored traditional Indian medicinal plant of north eastern region of India, is routinely used as folklore medicine to treat various ailments in particular urolithiasis and medharasayana drug. The objective of the study was to evaluate antiamnesic potentiality of Crataeva nurvala stem bark extract through different learning and memory paradigm against scopolamine induced cognitive impairment. Ethanolic extract of Crataeva nurvala (100, 200 and 400 mg/kg) was administered to adult Wistar rats for successive 14 days and the acquisition, retention and retrieval of spatial recognition memory was determined in-vivo. Further, whole brain cholinesterase activity was estimated in rat brain homogenate. Pre-treatment with Crataeva nurvala extract significantly improved transfer latency against scopolamine induced amnesia in-vivo. Moreover, it significantly decreased rat brain acetyl cholinesterase activity in a dose dependent manner and comparable to the standard drug Piracetam. Thus, the result confirmed folk use of Crataeva nurvala in cognitive improvement the plant could be viewed as a potential source of natural antiamnesic compound.
Key words: Crataeva nurvala, Antiamnesic, Cholinesterase