Research Programme

Research  Programme at Assam Down Town University

 

The research policy of Assam down town University aims to generate and support a research culture among its faculties and students and leverage it for enriching and increasing the professional capability of the faculty members. The faculties of Assam down town University are involved in sustainability-focused research, in addition to teaching responsibilities. The university has initiated research work along with Ph.D programme in the areas of Diabetes,Tuberculosis ,molecular studies of  cancer, Green Synthesis of nano-particles and their application in health , environment and pollution ,functional properties of bio-molecules from medicinal plants against various diseases in Agri-crops, infectious & non-infectious diseases like Jaundice and artificial intelligence etc

Assam down town University is the first private University from North East region being awarded the 2nd Mega Network Project entitled “Characterization of high value phytochemicals of anti-diabetic and immunomodulatory properties in North Eastern banana varieties” funded by Department of Biotechnology, Govt. of India very recently along with other projects. This is net work project and more  than 10 Research institutions such as Tamil Nadu Agricultural University, Chennai, ICAR - National Research Centre for Banana, Tiruchirapalli, Institute of Life Sciences, Bhubaneswar, IIT Kharagpur, North Eastern Hill University, Shillong, IASST Assam, Mizoram university, Assam Agri University ,Translational Health Sciences & Technology, Faridabad. The project team from Assam down town University is coordinated by Dr. Ananya Kashyap and Ms. Daisy Sarma from Food Nutrition & Dietetics. The ultimate outcome of the project will be to analyze the complete profile of the high value phytochemicals of North Eastern bananas and to find out the glycemic index , anti-diabetic, anticancer and immunomodulatory properties in vitro and in vivo  to develop a therapeutic strategy.

The first mega network project “Chemical profiling of Joha and black rice of NER for Nutritional, Nutraceutical Parameters and Aromatic Compounds” was initiated in 2016 along with other research institutions/ Universities in the country. Through this, Assam down town University is now becoming the major partner of two mega network project linking with more than 100 top most research institutions and Universities in the country. This project aimed to profile antioxidant molecules present in certain Joha and black rice.

 

In this proposal, the research team will explore the antioxidant and hypolipidemic effectiveness of few Joha/black rice varieties in the light of a new experimental observation. The biomolecues associated with the rice varieties and their significant function to control the cholesterol and other lipid profiles related to the Cardiovascuilar diseases etc will be studied. The project is coordinated by Dr. Saikat Sen and Dr. Raja Chakraborty, Associate Professors, Department of Pharmacy.

The third project entitled “Foldscope a Tool for Evaluation of Genotoxic Effect of Food Preservatives: A Model Experiment for Under Graduate Students of Life Science” is also funded by the Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India and coordinated by Dr. Jyotchna Gogoi, Associate Professor, Department of Biochemistry. A total number of 445 approved schools/colleges/institutions/universities within NE region and other regions of India are taking part in the project. The total budget is around 30 crores. The outcome of the project is to find out simple technique by using biological tools to find out the toxic substances/ contaminants in the vegetables and food. The project is also aimed to train the students on such techniques and also make an awareness programs regarding the toxicity of such substances associated with vegetables and food items etc. This project will be implemented in semi urban high schools of Bonda, Panikhaiti and Chandrapur area of Gauhati. The outcome of the project would help the student to understand the toxicity at the gene level which leads to different types of health and environmental issues.

The fourth project entitled “Design and Fabrication of Portable Friction Welding Machine" supported by Department of Science & Technology, Govt. of India under a special scheme implemented by Assam Science Technology and Environment Council (ASTEC), Govt. of assam. The project is coordinated by Mr. Manash Jyoti Borah of Department of Mechanical Engineering. The main objective of this project is to make a simple device to join process/ welding easier, and also to make popularity of portable friction welding machine among small scale industries which will help in “MAKE IN INDIA” project. The device may also substitute the existing heavy and bulky welding machines.

The fifth project entitled “Development of APP for speaking English into Assamese and vice-versa” funded by Assam association of North America (AANA), USA an NGO to enhance social values of the assamese language. The project team comprises of Mr. Mriganka Sarmah and Mr. Gautam Borah. The main aim of this project is to make conversation easier and understandable between two persons speaking daily usable easy English sentences or Assamese. The project is under the broad area of Natural Language Processing which encompasses computational methods for determining the natural meaning of the spoken or written sentences.

 

Projects funded/ recommended/ under review (2018-2020) ICMR, DBT, DST and University Grant - in - aid project.

 

Sl no. Project Title Principal Investigator Funding agencies Total duration
1 Design and Fabrication of a portable friction stir welding machine Mr. Manash Jyoti Borah Mechanical Engineering Assam Science Technology and Environment Council (ASTEC), DST, Govt. of India 2 year
2 “Polymorphism and Expression Study of Heat Shock Protein gene in Cancer Cases from Assam” Dr. Manash Pratim Sarma Biotechnology Assam down town University (University Grant- in - aid project) 1 year
3 “Lead finding for acetylcholinesterase and butyrylcholinesterase inhibitors from folklore medicinal plants of North Eastern region of India” Dr. Atanu Bhattacharjee Pharmacy Assam down town University (University Grant- in - aid project) 1 year
4 “Design and fabrication of bio-digester and utilization of biogas from various wastes of Assam down town University and its nearby localities” Mr. Ridhiman Dutta Department of Mechanical Engineering Assam down town University (University Grant- in - aid project) 1 year
5 “Formulation and Evaluation of Topical Gel for Haemostatic and Antibacterial action” Mr. Rituraj Bharadwaj Department of Pharmacy Assam down town University (University Grant- in - aid project) 1 year
6 “Assess the level of depression, anxiety and stress among the faculties working in a selected University, Guwahati, Assam” Ms. Jolene Nongkynirh Department of Nursing Assam down town University (University Grant- in - aid project) 1 year
7 “IoT Based Smart LPG Monitoring and Controlling System” Mr. Prasanta Pratim Bairagi Department of Computer Science and Engineering Assam down town University (University Grant- in - aid project) 1 year
8 “Identification of Novel prognostic markers, intervention targets and development of novel therapies for Triple Negative Breast Cancer of North East India” Dr. Manash Pratim Sarma The mega net work project submitted to DG-ICMR jointly by BBCI & Assam down town University 3 year
9 “Outreach Programme for Creating Awareness and Sensitization about Cancer: “NE-Can”. Dr. Sthiti Porna Dutta (Biochemistry) DBT Twinning Program –under a special scheme -North East Region on studies on Cancer 3 year
10 “To study the relationship of MT-2, GSTM1 and CYP1A1, Genes and heavy metal and their impact on treatment of osteosarcoma patients”. Dr. Minakshi Bhattacharjee (Biotechnology) DBT Twinning Program (North East Region) 3 year
11 “Formulation and Evaluation of Dry Powder Inhaler Containing Targeted Paclitaxel Loaded Nanoformulation for Treatment of Lung Cancer”. Mr. Rituraj Bharadwaj (Pharmacy) DBT Twinning Program (North East Region) 3 year
12 “Arresting the oncogenic drive from endometriosis towards ovarian cancer by modulating Gas6 protein expression through bioactive compounds from V negundo” Dr. Minakshi Bhattacharjee (Biotechnology) Department of Biotechnology,Govt. of India Under Maternal and Child Health Programme  
13 “Developing a potential therapeutic lead for COPD through HSP Modulation using natural compounds” Dr. Minakshi Bhattacharjee (Biotechnology) Department of Biotechnology, Govt. of India Under Bio-Care  
14 Project Proposal of LOI Dr. Minakshi Bhattacharjee (Biotechnology) Department of Biotechnology, Govt. of India  
15 Program or scheme for the financial support under infrastructure development (FIST Capital project Level – 1) under Life sciences Dr. Manash Pratim Sarma (Biotechnology) Department of Science & Technology, Govt. of India  

 

Anti fungal activity of Christella hispidula plant extract, Salivary adipokines markers in OSCC, Development of functional food products for postmenopausal women of Manipur, Development of food products by using Capsicum chinese jacq. (King chilli), A study on prevalence of gastrointestinal tract cancers among the middle aged adults of Manipur, Development of various products from indigenous fruits of Manipur, Development of fiber rich nutrient bars from seasonally available fruits, A study on traditional healers and their healing practices among Meitei community of Manipur, Characterization and Evaluation of synthesized polymeric film against bacteria causing chronicity, Comparative study on neutraceutical and antioxidant activity of coloured scented rice of north east India, Characteristic evaluation of synthesized nanomaterials against bacteria causing wound infection, Medicinal plant based fibroin nanocapsule against chronic burn wound infection. Supramolecular amphiphilic fibroin based smart hydrogel for original tissue regeneration in burn wound injuries, Tea waste in nano-formulation; An effective remedy for Paronychia prevalent among tea workers, Genomic DNA isolation and amplification of XRCC and XPD gene in cancerous and healthy cases, Screening of phytochemicals and evaluation of anti-microbial, anti-oxidant and in-vitro anti-diabetic activity of crassula ovata leaves, Extraction of pesticide residues from vegetables (Cauliflower) collected from various markets of Guwahati, Study on genetic polymorphism of Glutathione S-transferase (GST) AND Heat Shock Protein (HSP) genes in liver disease cases from North East India, Endophyte isolation  and identification from different varieties of chili plant, Isolation of metal reducing microorganism from sewage water of jewellery making shop, Antifungal property of Citrus aurantifolia, Citrus lemon and Citrus grandis, Synthesis and Characterization of Reduced Iron Particles from sour plants of North-East India, Phytochemical analysis and isolation of compounds from methanolic leaf extract of Amaranthus spinosus and its antimicrobial effect against Staphylococcus aureus and  enteric bacteria, In vitro phytochemical screening of the bioactive metabolites of the root extract of Amaranthus  spinosus and estimation of its antimicrobial activity against oral pathogens, Green synthesis of Silver nanoparticles by Colocasia esculenta and Colocasia fontanesii and a comparative study of the antibacterial effect on opportunistic skin flora, Phytochemical screening and thin layer chromatographic studies of Flemingia vestita root extract and its properties against enterobacteriaceae, Isolation, identification and characterization of  biomolecules of Amaranthus spinosus plant from North Eastern region and its properties against jaundice, Development of Schiff and Mannich bases of Isatin and its derivatives with Quinazoline as potent anticancer agents, Development of 1, 3, 4-oxadiazole derivatives as potential anticancer agents, Design, Synthesis and characterization of quinazoline derivatives for the treatment of cancer, Design, Synthesis and characterization of Cu(II),Ni(II), Mn(II) and Fe(III) complexes with Quinazoline derivatives as Potent Multi Acting HDAC and Receptor Tyrosine Kinase Inhibitors for the Treatment of Cancer, Design, Synthesis and characterization of purine derivatives as potential Reverse transcriptase Inhibitors (RTIs) for the Treatment of HIV, In vitro and in silico studies of curcumin analogues, Synthesis of Mannich base curcumin derivatives and Bioactive peptide separation and evaluation of its nutritional importance.
In addition to this, in-house research activities as given below as a part of graduate/ post graduate programmes in different areas (Faculties of Sciences, Engineering & Technology, Pharmaceutical Sciences, Commerce, Management, Humanities & Social Sciences, Paramedical Sciences, Nursing) etc are also undertaken by the faculties of the University.

Simulation a model on Ambiguity Measure and Detection in Requirement Engineering”,“A Study of Different Data Encryption Algorithms at Security Level”., “Design and Implementation of Fault Tolerance System in Distributed Real Time Environment”., Study and Design of E-Banking Security using Crypto-Biometric Techniques”., Analytical Study on Cryptography and Network Security”., Application of Data mining Techniques in a small business organisation”., Simulation of Fault Tolerance Techniques and Algorithms in Cloud Computing Environment”., A Model on Cloud Computing for E-Governance Utilization: with special emphasis on Panchayats”., Signature schemes and their use in Digital Transactions: A study on the privacy of digitally transferred in formation, Use of data mining tools in HealthCare sectors: A Comparative study., Study and Analysis of Diabetic Risk Factor of Assamese Community of NEI  and , Study the Behavior of AIDS Related data of Patient of Assam to detect unknown characteristics through Data Mining Tools and Techniques, Knowledge acquisition keyword filtering techniques through Expert System in a corporate environment, Web content filtering from user’s browsing history and analysis through expert system in corporate environment, Design and development of Fuzzy based Evaluation Expert System in Educational environment,“ Present Trends of Data Protection Policies in Cloud Computing”., Automatic ways to download information from hidden web by using heuristic search method”., A comparative Study of Loose less Data Compression Techniques on Text Data and Image”., Partion Based Clustering Image Segmenation”., Analysis of C, FORTRAN, C# and Java Programming Languages”., An experimental study and design of adhesive bonded aluminium sheet metal., Pyrolytic Characterization and kinetic analysis of Camellia sinesis (tea) seed deoiled cake, Production of Bio-alcohol from water hyacinth, Comprehensive study on generation trend of Municipal Solid Waste in Guwahati city., Comprehensive study on different composting techniques, Design and fabrication of manual black board wiping mechanism,Experimental investigation on performance of a diesel engine using Cucurbita  Pepo L. seed oil methyl ester as fuel and its blends.,A techno-economic feasibility model of wind power projects in North-East India. ,Energy Audit of Assam down town University and Energy Efficiency using Renewable sources., Hydraulic Transients in Different Pipe Flow Situation: Numerical Modeling to Simulate the Transients”., Study on slope stability problem in northeast India with special reference to Panikhaiti Hills”., Study, Analysis and modeling of flow and resistance in open channel and its importance for proper flood prediction” and analytical study and modeling of flow prediction and resistance on compound channel”.

Analyze and design a four storey R.C.C. building suitable for a highly seismic region like the North-Eastern Region which falls in zone 5 of seismicity of India”., Comparative study of Stabilization of Soil using coconut fiber & Fly Ash, Evaluation of ma properties of Bituminous mix and ma write materials as timers  ,Study on pile raft foundation by FEM using plaxio 3D foundation, Concrete Mix Design using some additional material, Analysis of flow around impermeable spur on one side of channel: on experimental study, Study on effects of leach ate on soil characteristics  ,Analysis of traffic condition in Guwahati City- A case study, Planning and Design of drainage system from Maligaon micro watershed to Deepar Beel, Analysis and Design of RC shear for Allied Health building at AdtU, Water Quality in Nambul River and Water Pollution Management, An index based inundation mapping in the Brahmaputra River, Experimental study on fibre reinforced concrete, Study of the properties of bituminous mixes using rice husk ash & pottery clay as filer material, Engineering Properties of fined grained soil, Performance Analysis of rotary intersection,, Design of railway over bridge, Infiltration studies for discharge  soil sample by using both physical & numerical method, Structural behavior of P.C.C. using wire wash ,Study of effect of admixture in soil stabilizations, Frequency and regression analysis of rainfall and discharge data, A comparative study and analysis of effect of difficult kinds of media in Water filter, Seasonal analysis of NDVI change in poponpare dist – Remote sensing, Stabilized soil block (using sugarcane baggage ash) and Effect of Fly ash on compressive strength of concrete. 

University is having MoU’s with some of the best R&D institutions of the country such as CSIR-North East Institute of Science and Technology (DSIR, Govt of India)- Jorhat, Guwahati Biotech Park – Guwahati,  Institute of  Advanced  study in Science and Technology, Guwahati (Govt. Of India), Dr. Bhubaneswar Borooah Cancer Institute ( DAE, Govt. of India), National Institute of Pharmaceutical Education and Research (Ministry of Chemicals and fertilizer, Govt. of India), Guwahati, National Research Development Corporation  ( DSIR, DST Govt. of India)– New Delhi

The faculties of university has published more than 350 research papers in leading national and international journal and filed patents as well. The University is already recognized by Department of Science & Technology as a research organization and received SIRO Certificate. University is also having Animal house facilities approved by the Govt of India to undertake research studies using small animals. The collective outcome of the research activities of the University utilizing the richest resources of this region may bring a significant achievement in research front, and will be very much useful for the people

 

Dr. B G Unni
Director Research
Oct 2018

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